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Table 4 Treatment failure: Monotherapy vs. Combination therapy

From: Treatment of Klebsiella Pneumoniae Carbapenemase (KPC) infections: a review of published case series and case reports

 

Monotherapy (%)

Combination (%)

P

Overall treatment failure

24/49(49)

14/56(25)

0.01

Source:

   

Blood

12/24 (50)

9/32(28)

0.09

Pulmonary

10/15(67)

5/17(29)

0.03

Urine

1/8(13)

0/3(0)

0.4

Polymyxin treatment failure

8/11(73)

10/34(29)

0.02

Carbapenem treatment failure

12/20(60)

5/19(26)

0.03

Tigecycline treatment failure

2/7(29)

7/19(37)

0.4

Aminoglycoside treatment failure

0/6(0)

4/24(17)

0.6