From: Treating tuberculosis with high doses of anti-TB drugs: mechanisms and outcomes
Types of patients | Mechanisms | References |
---|---|---|
Common pulmonary TB with low-dose prescription | Some patients are underdosed even at standard doses | |
Fixed-dose combination with at least one low drug level in the serum | ||
Patients with slow response to TB treatment | Low serum level of Cmax 2Â h post-dose | [126] |
Patients with difficult TB | Difficult to increase the drug serum level | [106] |
Patients with TB and HIV | Poor exposure to anti-TB drugs | |
Interaction between anti-HIV and anti-TB drugs | [129] | |
Patients with TB and diabetes mellitus | Decreased exposure to anti-TB drugs | [130] |
Differences in hepatic induction | [131] |