Table 2 List of variants found in study strains and their clinical significance
Gene | Related drug | Nucleotide change | Suspected amino acid changes | No. of strains having variant among sensitive strains (%) | No. of strains having variant among resistant strains (%) | P value* | Previous report | Interpretation |
|---|---|---|---|---|---|---|---|---|
gyrA | FQ | G61C | E21Q | 30/30 (100) | 6/6 (100) | > 0.05 | Yes [22] | Susceptible |
gyrA | FQ | C269T | A90V | 0/30 (0) | 2/6 (33.3) | 0.024 | Yes [23] | Resistance |
gyrA | FQ | G280A | D94N | 0/30 (0) | 1/6 (16.7) | 0.17 | Yes [23] | Possible resistance |
gyrA | FQ | A281G | D94G | 0/30 (0) | 1/6 (16.7) | 0.17 | Yes [23] | Possible resistance |
gyrA | FQ | G284C | S95T | 29/30 (96.7) | 6/6 (100) | > 0.05 | Yes [16] | Susceptible |
gyrA | FQ | C846G | N282K | 3/30 (10) | 1/6 (16.7) | 0.17 | No | Susceptible |
gyrA | FQ | G2003A | G668D | 29/30 (96. 7) | 6/6 (100) | > 0.05 | Yes [22] | Susceptible |
rpsL | SM | A128G | K43R | 0/26 (0) | 3/10 (30) | 0.017 | Yes [24] | Resistance |
rpsL | SM | A262C | K88Q | 0/26 (0) | 1/10 (10) | 0.298 | Yes [24] | Possible resistance |
embB | EMB | A916G | M306V | 1/29 (3.4) | 3/7 (42.9) | 0.018 | Yes [16] | Resistance |
embB | EMB | G918A | M306I | 0/29 (0) | 2/7 (28.6) | 0.033 | Yes [16] | Resistance |
embB | EMB | A916C | M306L | 0/29 (0) | 1/7 (14.3) | 0.194 | Yes [16] | Possible resistance |
embB | EMB | A956C | Y319S | 0/29 (0) | 1/7 (14.3) | 0.22 | Yes [16] | Possible resistance |
embB | EMB | A1061D | D354A | 1/29 (3.4) | 0/7 (0) | > 0.05 | Yes [25] | Susceptible |
embB | EMB | A1255G | I419V | 0/29 (0) | 1/7 (14.3) | 0.194 | No | Possible resistance |
inhA | INH | T62C | I21T | 0/21 (0) | 1/15 (6.7) | > 0.05 | Yes [16] | Possible resistance |
inhA | INH | T74C | I25T | 0/21 (0) | 1/15 (6.7) | > 0.05 | Yes [26] | Possible resistance |
inhA | INH | T280G | S94A | 0/21 (0) | 2/15 (13.3) | 0.167 | Yes [16] | Possible resistance |
katG | INH | 923_924delinsAG | T308L | 1/21 (4.8) | 0/15 (0) | > 0.05 | No | Susceptible |
katG | INH | C944G | S315T | 0/21 (0) | 5/15 (33.3) | < 0.05 | Yes [16] | Resistance |
katG | INH | C944T | S315N | 0/21 (0) | 1/15 (6.7) | > 0.05 | Yes [16] | Possible resistance |
katG | INH | A1133C | L378R | 0/21 (0) | 1/15 (6.7) | > 0.05 | No | Possible resistance |
katG | INH | C1317A | Q439H | 1/21 (4.8) | 0/15 (0) | > 0.05 | No | Susceptible |
katG | INH | C1388A | R463L | 16/21 (76.2) | 12/15 (80) | > 0.05 | Yes [16] | Susceptible |
katG | INH | G1595A | A532V | 1/21 (4.8) | 0/15 (0) | > 0.05 | No | Susceptible |
katG | INH | G1715A | T572M | 1/21 (4.8) | 0/15 (0) | > 0.05 | No | Susceptible |
katG | INH | A1789C | Y597D | 0/21 (0) | 1/15 (6.7)) | > 0.05 | No | Possible resistance |
katG | INH | T1873C | T625A | 1/21 (4.8) | 2/15 (13.3) | > 0.05 | No | Susceptible |
pncA | PZA | C53A | S18Ter | 0/28 (0) | 1/8 (12.5) | > 0.05 | No | Possible resistance |
pncA | PZA | A139C | T47P | 0/28 (0) | 1/8 (12.5) | > 0.05 | Yes [16] | Possible resistance |
pncA | PZA | 241insT | H82Pfs | 0/28 (0) | 1/8 (12.5) | > 0.05 | No | Possible resistance |
pncA | PZA | T254G | L85R | 0/28 (0) | 1/8 (12.5) | > 0.05 | Yes [16] | Possible resistance |
rpoB | RFP | C38T | P13L | 1/25 (4) | 0/11 (0) | > 0.05 | No | Susceptible |
rpoB | RFP | C1333T | H445Y | 0/25 (0) | 1/11 (9.1) | > 0.05 | Yes [27] | Possible resistance |
rpoB | RFP | C1349T | S450L | 0/25 (0) | 10/11 (90.9) | < 0.001 | Yes [27] | Resistance |
rpoB | RFP | T1355C | L452P | 1/25 (4) | 0/11 (0) | > 0.05 | Yes [27] | Susceptible |
rpoB | RFP | G1655T | R552L | 0/25 (0) | 1/11 (9.1) | > 0.05 | No | Possible resistance |
rpoB | RFP | G1882T | A628S | 1/25 (4) | 0/11 (0) | > 0.05 | No | Susceptible |
rpoB | RFP | A3305C | K1102T | 1/25 (4) | 0/11 (0) | > 0.05 | No | Susceptible |