Table 3 Patient outcomes by area under the curve for 24 h
From: The risk of vancomycin toxicity in patients with liver impairment
Variable | AUC:MIC < 400 | 400 ≤ AUC:MIC ≤ 600 | AUC:MIC > 600 | P-value |
|---|---|---|---|---|
(n = 71) | (n = 247) | (n = 90) | ||
Acute kidney injury, n (%) | 3 (4.2) | 11 (4.5) | 8 (8.9) | 0.2879 |
Mortality, n (%) | 10 (14.1) | 17 (6.9) | 7 (7.8) | 0.1502 |
Length of hospital stay, mean ± SD (days) | 11.5 ± 7.6 | 9.8 ± 9.1 | 13.0 ± 10.5 | 0.0015 |
Vancomycin trough concentration, mean ± SD (µg/mL) | 10.4 ± 3.8 | 14.9 ± 3.3 | 24.5 ± 8.4 | < 0.0001 |
Vancomycin clearance (ml/min) | 6.6 ± 3.2 | 5.5 ± 2.0 | 4.1 ± 1.5 | < 0.0001 |