Factor | Survivors (%) | Deceased (%) | p value |
---|---|---|---|
(n = 169) | (n = 46) | ||
Demographics | |||
Age, median (IQR) | 75 (64–84) | 81 (72–86) | 0.001 |
Male sex | 96 (56.8) | 26 (56.5) | |
BMI, median (IQR) | 19.8 (18.4–22.1) | 19.8 (18.5–22.1) | |
Community onset | 140 (82.8) | 34 (73.9) | |
Nosocomial onset | 29 (17.2) | 12 (26.1) | |
Comorbidities | |||
HIV infection | 0 | 0 | |
ESRD on hemodialysis | 9 (5.3) | 4 (8.7) | |
Diabetes mellitus | 34 (20.1) | 17 (37.0) | 0.02 |
Cirrhosis | 2 (1.2) | 2 (4.3) | |
CHF | 22 (13.0) | 9 (19.6) | |
COPD or severe asthma | 3 (1.8) | 0 | |
Solid tumor | 44 (26.0) | 18 (39.1) | |
Hematological malignancy | 8 (4.7) | 3 (6.5) | |
Alcoholism | 3 (1.8) | 1 (2.2) | |
Steroid use | 9 (5.3) | 6 (13.0) | |
Charlson Comordity Index | 4 (3–6) | 6 (5–9) | < 0.001 |
Characteristics at presentation | |||
Fever | 125 (74.0) | 22 (47.8) | < 0.001 |
Neutropenia | 5 (3.0) | 4 (8.7) | |
Creatinine, median (IQR) | 1.0 (0.7–1.4) | 1.2 (0.8–2.0) | |
Lactate, median (IQR) | 2.2 (1.4–3.3) | 3 (1.5–7.4) | 0.02 |
Central line catheter | 9 (5.3) | 2 (4.3) | |
Urinary catheter | 3 (1.8) | 0 | |
Primary source | |||
Oropharyngeal | 14 (8.3) | 0 | 0.04 |
Soft tissue infection | 9 (5.3) | 3 (6.5) | |
Central venous catheter | 3 (1.8) | 0 | |
Hepatobiliary infection | 20 (11.8) | 6 (13.0) | |
Intra-abdominal | 62 (36.7) | 17 (37.0) | |
Bone and joint | 3 (1.8) | 0 | |
Urinary tract infection | 8 (4.7) | 1 (2.2) | |
Bacteremia | |||
Polymicrobial bacteremia | 70 (40.2) | 22 (47.8) | |
No. of bacteremic pathogen, median (IQR) | 1 (1–2) | 1 (1–2) | |
Bacteroides spp | 44 (25.3) | 16 (34.8) | |
Non-spore forming bacillis | 46 (26.4) | 11 (23.9) | |
Clostridium spp | 33 (19.0) | 19 (41.3) | 0.009 |
Treatment | |||
Initial inappropriate therapy | 30 (18.5) | 10 (21.7) | |
Surgical procedure | 47 (27.8) | 4 (8.7) | 0.04 |
Vasopressor support | 28 (16.6) | 15 (32.6) | 0.02 |
Ventilatory support | 20 (11.8) | 8 (17.4) | |
Length of hospital stay, median (IQR) | 24 (15–35) | 14 (2–30) | 0.001 |
Pitt bacteremia score, median (IQR) | 1 (0–3) | 3 (1–6) | < 0.001 |