Characteristic | Total | Complete cohort (N = 180) | Cohort adjusted by PSMa | ||||
---|---|---|---|---|---|---|---|
BLICs | Carbapenems | P | BLICs | Carbapenems | P | ||
N (%) | 180 | N = 114 (63.3%) | N = 66 (36.7%) | N = 63 (59.4%) | N = 43 (40.6%) | ||
Age, years | |||||||
Mean (SD) | 59.3 (13.1) | 61.7 (12.4) | 55.2 (13.3) | 0.001 | 58.2 (12.3) | 55.7 (11.9) | 0.469 |
Sex, N (%) | |||||||
Male | 91 (50.6) | 58 (50.9) | 33 (50.0) | 0.910 | 30(47.6) | 22 (51.2) | 0.720 |
Female | 89 (49.4) | 56 (49.1) | 33 (50.0) | 33 (52.4) | 21 (48.8) | ||
Acquisition, N (%) | |||||||
Hospital-acquired | 117 (65.0) | 71 (62.3) | 46 (69.7) | 0.315 | 41 (65.1) | 32 (74.4) | 0.308 |
Community-associated | 63 (35.0) | 43 (37.7) | 20 (30.3) | 22 (34.9) | 11 (25.6) | ||
Length, median (IQR) | |||||||
Length of hospital stay | 20.5 (12–30) | 18 (11–28) | 24 (14–32) | 0.016 | 20 (11–29) | 25 (14–32) | 0.055 |
Severity of condition, median (IQR) | |||||||
aCCI | 3 (2–5) | 4 (2–6) | 3 (2–4.25) | 0.036 | 3 (2–5) | 3 (2–4) | 0.797 |
Pitt bacteraemia score | 1 (0–2.75) | 1 (0–2) | 2 (1–4) | 0.000 | 1 (0–2) | 1 (0–2.5) | 0.995 |
SOFA score | 3 (2–6) | 3 (1–5) | 5 (2.75–9) | 0.000 | 4 (2–6) | 3 (1.3–6) | 0.517 |
Underlying diseases, N (%) | |||||||
Immune compromise | 35 (19.4) | 15 (13.2) | 20 (30.3) | 0.005 | 13 (20.6) | 13 (30.2) | 0.259 |
Leukaemia | 13 (7.2) | 3 (2.6) | 10 (15.2) | 0.002 | 3 (4.8) | 7 (16.3) | 0.086 |
Arrhythmia | 16 (8.9) | 11 (9.6) | 5 (7.6) | 0.638 | 5 (7.9) | 3 (7.0) | 1.000 |
Hypertension | 42 (23.2) | 27 (23.7) | 15 (22.7) | 0.884 | 12 (19.0) | 7 (16.3) | 0.970 |
Diabetes | 20 (11.1) | 14 (12.3) | 6 (9.1) | 0.512 | 6 (9.5) | 2 (4.7) | 0.469 |
Hypoproteinaemia | 47 (26.1) | 32 (28.1) | 15 (22.7) | 0.432 | 16 (25.4) | 9 (20.9) | 0.820 |
Bacteria, N (%) | 0.448 | 0.778 | |||||
Escherichia coli | 147 (81.7) | 95 (83.3) | 52 (78.8) | 54 (85.7) | 36 (83.7) | ||
Klebsiella pneumoniae | 33 (18.3) | 19 (16.7) | 14 (21.2) | 9 (14.3) | 7 (16.3) | ||
Empirical treatment, N (%) | 0.268 | 0.154 | |||||
Appropriate | 159 (88.3) | 103(90.4) | 56 (84.8) | 60 (95.2) | 37 (86.0) | ||
Inappropriate | 21 (11.7) | 11 (9.6) | 10 (15.2) | 3 (4.8) | 6 (14.0) |