Table 1 Patient characteristics and M. abscessus complex (MABSC) clinical isolates
Characteristics | N (%) of patients | p-value | |||
|---|---|---|---|---|---|
Total (N = 74) | MAB (N = 28) | MBO (N = 3) | MMA (N = 43) | ||
Age (a), median (IQR), years | 64 (49.5–70) | 65.5 (48.5–69) | 33 (b) | 64 (50–71) | 0.11 |
Sex, Female | 50 (67.6) | 19 (67.9) | 1 (33.3) | 30 (69.8) | 0.424 |
Comorbidities | Â | Â | Â | Â | Â |
   Acquired immunodeficiency | 20 (27.0) | 9 (32.1) | 2 (66.7) | 9 (20.9) | 0.147 |
     • Adult-onset IFN-γ autoantibody syndrome | 8 (10.8) | 4 (14.3) | 1 (33.3) | 3 (7.0) | 0.177 |
      • Hematologic malignancy | 3 (4.1) | 1 (3.6) | 1 (33.3) | 1 (2.3) | 0.169 |
      • Solid malignancy | 8 (10.8) | 3 (10.7) | 0 | 5 (11.6) | 1 |
      • Immunosuppressive treatment | 1 (1.4) | 1 (3.6) | 0 | 0 | 0.419 |
   Structural lung diseases | 28 (37.8) | 11 (39.3) | 0 | 17 (39.5) | 0.593 |
      • Chronic bronchiectasis | 18 (24.3) | 6 (21.4) | 0 | 12 (27.9) | 0.641 |
      • TB-induced bronchiectasis | 8 (10.8) | 4 (14.3) | 0 | 4 (9.3) | 0.791 |
      • NTM-PD induced chronic bronchiectasis | 2 (2.7) | 1 (3.6) | 0 | 1 (2.3) | 1 |
   Procedure-related disease | 7 (9.5) | 1 (3.6) | 0 | 6 (14.0) | 0.433 |
   No underlying disease identified | 19 (25.7) | 7 (25.0) | 1 (33.3) | 11 (25.6) | 1 |
                              Total | 74 (100.0) | 28 (100.0) | 3 (100.0) | 43 (100.0) | 0.42 |
Types of infections | Â | Â | Â | Â | Â |
   NTM pulmonary colonization | 32 (43.2) | 10 (35.7) | 0 | 22 (51.2) | 0.167 |
   NTM-PD | 13 (17.6) | 7 (25.0) | 0 | 6 (14.0) | 0.462 |
   Extrapulmonary disease | 29 (39.2) | 11 (39.3) | 3 (100.0) | 15 (34.9) | 0.088 |
      • Disseminated | 8 (10.8) | 4 (14.3) | 2 (66.7) | 2 (4.7) | 0.014 * |
      • Lymphadenitis | 6 (8.1) | 4 (14.3) | 0 | 2 (4.7) | 0.384 |
      • Skin and soft tissue infection | 15 (20.3) | 3 (10.7) | 1 (33.3) | 11 (25.6) | 0.227 |
                              Total | 74 (100.0) | 28 (100.0) | 3 (100.0) | 43 (100.0) | 0.172 |
Outcomes(c) | N (%) of patients | p-value | |||
Total (N = 31) | MAB (N = 14) | MBO (N = 3) | MMA (N = 14) | ||
   Clinical cure | 18 (58.1) | 7 (50.0) | 2 (66.7) | 9 (64.3) | 0.869 |
   Culture conversion | 1 (3.2) | 0 | 0 | 1 (7.1) | 1 |
   Died from NTM | 4 (12.9) | 3 (21.4) | 0 | 1 (7.1) | 0.737 |
   Treatment failure | 7 (22.6) | 4 (28.6) | 1 (33.3) | 2 (14.3) | 0.572 |
   Died from other conditions | 1 (3.2) | 0 | 0 | 1 (7.1) | 1 |
                             Total | 31 (100.0) | 14 (100.0) | 3 (100.0) | 14 (100.0) | 0.793 |