Fig. 6

Meropenem can be hydrolyzed by OMV-associated KPC. a Disks from 1 to 5 contained indicated solutions. b Inhibition zones resulting from incubation of E. coli ATC25922, with 8 μg/mL meropenem exposure to free KPC or/and OMV-associated KPC, with or without pretreatment with proteinase K or/and Triton X-100. c Summarized data of diameters of inhibition zones in three independent experiments, expressed as means ± SD. **p < 0.01, ***p < 0.001