Efficacy and nephrotoxicity of polymyxin B in elderly patients with carbapenem resistant bacterial infection

Table 5 The value of APACHEII, SCr before PB use, PB duration and their combination in predicting AKI in elderly CRO infected patients

Indicator	AUC	Youden index	Cut-off	Sensitivity (%)	Specificity (%)
APACHEII	0.693	0.504	14.5	83.8	66.7
SCr before PB use	0.931	0.805	73	97.5	83
PB duration	0.792	0.573	10.5	86.5	67.4
Combination of the three	0.965	0.859	0.228	100	85.9
SCr combination APACHEII	0.930	0.782	0.357	93.8	84.4

PB, polymyxin B; Scr, serum creatinine; AKI: acute kidney injury; CRO, carbapenem resistant organism; AUC, area under the curve

ISSN: 1476-0711