Table 1 β-lactamase genotypes, and the effects of different inoculum sizes on the antibacterial MICs of CZA and IMR against E. coli and K. pneumoniae

E. coli

ATCC 25922

–

0.06/4

0.25/4

 > 512/4

0.03/8

0.125/8

64/8

0.125/4

0.25/4

 > 512/4

0.007/8

0.03/8

64/8

56,706*

bla_TEM-1, bla_AmpC

0.03/4

2/4

 > 512/4

0.015/8

0.125/8

128/8

0.06/4

0.125/4

 > 512/4

0.007/8

0.03/8

64/8

93,174

bla_AmpC, bla_CTX-M-14, bla_OXA-10

0.25/4

1/4

 > 512/4

0.125/8

0.5/8

512/8

0.125/4

0.25/4

 > 512/4

0.03/8

0.06/8

128/8

19–3

bla_CTX-M-14

0.03/4

0.25/4

 > 512/4

0.015/8

0.125/8

128/8

0.06/4

0.25/4

 > 512/4

0.007/8

0.03/8

64/8

1564

bla_CTX-M-55, bla_CMY-42, bla_TEM-1b, bla_CTX-M-14

8/4

32/4

 > 512/4

4/8

16/8

256/8

0.125/4

0.25/4

 > 512/4

0.03/8

0.03/8

128/8

E. coli

144,539

bla_CTX-M-55

4/4

4/4

512/4

1/8

2/8

64/8

0.5/4

1/4

512/4

0.25/8

0.25/8

64/8

K. pneumoniae

ATCC BAA-1705*

bla_KPC-2, bla_OXA-9, bla_SHV-182

0.125/4

1/4

 > 512/4

0.03/8

0.125/8

64/8

0.25/4

0.5/4

 > 512/4

0.007/8

0.03/8

16/8

ATCC-700603

bla_SHV-18, bla_OXA-2,

bla_OKP-B-7

0.03/4

0.25/4

 > 512/4

0.015/8

0.06/8

64/8

0.03/4

0.25/4

 > 512/4

0.007/8

0.03/8

32/8

50,666

bla_CTX-M-14, bla_KPC-2

0.25/4

2/4

 > 512/4

0.06/8

1/8

256/8

0.5/4

2/4

 > 512/4

0.125/8

0.25/8

128/8

52,582

bla_DHA-1, bla_OXA-1, bla_SHV-187

128/4

256/4

 > 512/4

8/8

32/8

512/8

128/4

256/4

 > 512/4

2/8

4/8

128/8

60,700*

bla_DHA-1, bla_SHV-27

0.25/4

2/4

 > 512/4

0.125/8

0.25/8

128/8

0.06/4

0.125/4

 > 512/4

0.03/8

0.03/8

64/8

61,089*

bla_KPC-2, bla_CTX-M-65, bla_SHV-11

0.125/4

2/4

 > 512/4

0.06/8

0.5/8

64/8

0.06/4

0.25/4

 > 512/4

0.007/8

0.03/8

32/8

79,528

bla_CTX-M-15, bla_SHV-27, bla_TEM-1b

0.25/4

4/4

 > 512/4

0.125/8

2/8

512/8

0.25/4

2/4

 > 512/4

0.03/8

1/8

256/8

47,709

bla_SHV-145

0.125/4

0.125/4

 > 512/4

0.06/8

0.06/8

128/8

0.06/4

0.25/4

 > 512/4

0.03/8

0.06/8

64/8

50,604

bla_SHV-12, bla_KPC-2

0.5/4

0.5/4

 > 512/4

0.125/8

0.25/8

64/8

0.06/4

1/4

 > 512/4

0.03/8

0.5/8

64/8

K. pneumoniae

61,638

bla_CTX-M-65, bla_KPC-2

1/4

8/4

 > 512/4

0.25/8

2/8

32/8

0.125/4

2/4

 > 512/4

0.03/8

0.5/8

64/8

62,291

bla_SHV-106, bla_KPC-2

0.5/4

2/4

 > 512/4

0.125/8

0.5/8

128/8

2/4

2/4

 > 512/4

1/8

1/8

64/8

62,478

bla_SHV-110

0.125/4

0.25/4

 > 512/4

0.06/8

0.125/8

64/8

0.06/4

0.25/4

 > 512/4

0.03/8

0.06/8

32/8

78,050

bla_SHV106, bla_KPC-2

0.5/4

32/4

 > 512/4

0.125/8

8/8

128/8

0.125/4

1/4

 > 512/4

0.06/8

0.5/8

128/8