Table 2 Risk factors for active tuberculosis development after transplantation
Risk factors | Univariate | Multivariate | |||
|---|---|---|---|---|---|
HR (95% CI) | P-value | HR (95% CI) | P-value | ||
Age (years) | 0–19 | 0.48 (0.32, 0.71) | < 0.001 | 0.46 (0.31, 0.69) | < 0.001 |
20–39 | 1 (ref.) | 1 (ref.) | |||
40–59 | 1.18 (0.97, 1.44) | 0.09 | 1.21 (0.99, 1.48) | 0.06 | |
> 60 | 1.58 (1.26, 1.97) | < 0.001 | 1.65 (1.30, 2.08) | < 0.001 | |
Sex | M | 1.412 (1.22, 1.64) | < 0.001 | 1.38 (1.19,1.61) | < 0.001 |
F | 1 (ref.) | 1 (ref.) | |||
Diabetes mellitus | Yes | 1.26 (1.10, 1.44) | 0.001 | 1.120 (0.97, 1.29) | 0.13 |
No | 1 (ref.) | 1 (ref.) | |||
Hypertension | Yes | 1.07 (0.93, 1.22) | 0.37 | 0.97 (0.82, 1.15) | 0.73 |
No | 1 (ref.) | 1 (ref.) | |||
Asthma | Yes | 0.93 (0.76, 1.14) | 0.49 | 0.97 (0.78, 1.20) | 0.77 |
No | 1 (ref.) | 1 (ref.) | |||
COPD | Yes | 0.99 (0.73, 1.35) | 0.95 | 0.85 (0.62, 1.18) | 0.34 |
No | 1 (ref.) | 1 (ref.) | |||
Liver Cirrhosis | Yes | 1.17 (1.00, 1.37) | 0.05 | 0.90 (0.67, 1.20) | 0.46 |
No | 1 (ref.) | 1 (ref.) | |||
Chronic kidney disease | Yes | 1.00 (0.87, 1.15) | 0.96 | 1.46 (0.98, 2.19) | 0.07 |
No | 1 (ref.) | 1 (ref.) | |||
Previous TB history | Yes | 1.54 (1.11, 2.14) | 0.010 | 1.48 (1.06, 2.07) | 0.02 |
No | 1 (ref.) | 1 (ref.) | |||
Transplantation | Liver | 1.17 (0.98, 1.39) | 0.08 | 1.71 (1.04, 2.80) | 0.034 |
Kidney | 1 (ref.) | 1 (ref.) | |||
Heart | 1.00 (0.63, 1.59) | 0.99 | 1.39 (0.80, 2.41) | 0.25 | |
Lung | 1.42 (1.78, 2.60) | 0.25 | 1.88 (1.90, 3.92) | 0.09 | |
Others | 1.59 (0.59, 4.25) | 0.36 | 2.55 (0.89, 7.30) | 0.08 | |
Allogeneic HSCT | 1.20 (1.00, 1.44) | 0.05 | 2.14 (1.37, 3.34) | < 0.001 | |
Autologous HSCT | 0.68 (0.54, 0.87) | 0.002 | 1.01 (0.64, 1.57) | 0.97 | |