Table 2 Comparison of primary and secondary outcome measures before and after implementation of the syndromic gastrointestinal pathogen panel at the pediatric ED
Mean monthly rate (%) (95% CI) | |||
|---|---|---|---|
Pre-implementation | Post-implementation | P value | |
Primary outcome: Clinical decision parameters | |||
Broad-spectrum antibiotic use at discharge | 15.8 (14.4–17.2) | 9.9 (8.5–11.5) | < 0.001 |
Broad-spectrum antibiotic use at admission | 66.0 (61.1–70.6) | 52.2 (47.1–57.3) | < 0.001 |
Overall broad-spectrum antibiotic use | 25.9 (24.2–27.6) | 22.6 (20.5–24.7) | 0.016 |
Abdomen CT prescription | 15.0 (13.7–16.4) | 17.2 (15.3–19.1) | 0.066 |
Abdomen ultrasound prescription | 5.4 (4.5–6.3) | 4.4 (3.5–5.6) | 0.214 |
Transmission and isolation consults | 1.0 (0.7–1.5) | 4.7 (3.7–5.9) | < 0.001 |
Time taken for infection prevention intervention (days) | 1.7 (1.7–1.8) | 0.5 (0.5–0.6) | < 0.001 |
Secondary outcomes: Patient outcome parameters | |||
Duration of ED stay (hours) | 5.5 (5.4–5.7) | 6.5 (6.3–6.8) | < 0.001 |
ED revisit | 5.2 (4.4–6.1) | 2.6 (1.9–3.5) | < 0.001 |
Need for admission at follow up (via OPD) | 2.1 (1.6–2.7) | 0.8 (0.4–1.4) | 0.030 |
Disease progression rate | 0.3 (0.2–0.7) | 0.4 (0.1–0.8) | 1.000 |