Table 1  Results of fill and trim, egger and begg test, and fail-safe

Penicillins

Ampicillin

0.669

0.097

232

0.941 (0.850, 0.978)

Carbenicillin

0.051

> 0.999

16

0.760 (0.413, 0.935)

Ticarcillin

0.012

0.169

1290

0.766 (0.675, 0.837)

Piperacillin

0.949

0.619

3728

0.671 (0.581, 0.750)

Phosphonic antibiotic

Fosfomycin

0.680

> 0.999

0

0.440 (0.229, 0.675)

Monobactams

Aztreonam

0.072

0.615

6624

0.905 (0.870, 0.932)

β-lactam/β-lactamase inhibitor

Amoxicillin/ clavulanate

0.248

0.731

126

0.784 (0.589, 0.901)

Ampicillin/sulbactam

0.315

> 0.999

24

0.876 (0.599, 0.971)

Aztreonam/ clavulanate

< 0.001

0.333

68

0.796 (0.602, 0.910)

Cefperazone/sulbactam

0.166

0.163

463

0.253 (0.140, 0.415)

Ceftazidime/avibactam

< 0.001

0.399

0

0.480 (0.290, 0.675)

Piperacillin/tazobactam

0.771

0.765

8069

0.623 (0.568, 0.675)

Ticarcillin/clavulanate

0.119

0.302

23,374

0.337 (0.285, 0.393)

Cephalosporins

Ceftazidime

0.016

0.432

0

0.456 (0.427, 0.486)

Cefazolin

0.003

0.817

11

0.494 (0.157, 0.836)

Cefepime

0.555

0.605

5321

0.673 (0.607, 0.733)

Cefiderocol

0.013

0.239

46

0.101 (0.004, 0.758)

Cefoperazone

0.102

0.675

0

0.509 (0.329, 0.687)

Cefotaxime

0.086

0.741

2388

0.780 (0.688, 0.850)

Cefoxitin

0.956

> 0.999

38

0.964 (0.920, 0.985)

Ceftizoxime

0.598

> 0.999

23

0.897 (0.419, 0.991)

Ceftriaxone

0.315

0.229

3851

0.884 (0.816, 0.930)

Cefuroxime

0.848

0.817

99

0.950 (0.903, 0.975)

Carbapenems

Imipenem

< 0.001

< 0.001

20,049

0.921 (0.883, 0.947)

Meropenem

0.277

0.306

11,163

0.852 (0.792, 0.897)

Doripenem

0.100

> 0.999

81

0.963 (0.887, 0.989)

Ertapenem

0.060

0.719

42

0.750 (0.527, 0.890)

Aminoglycosides

Amikacin

0.259

0.342

13,594

0.702 (0.655, 0.744)

Gentamicin

0.061

0.055

16,886

0.722 (0.674, 0.766)

Netilmicin

0.188

0.697

16

0.550 (0.318, 0.762)

Tobramycin

0.302

0.594

4895

0.730 (0.679, 0.775)

fluoroquinolones

Gatifloxacin

0.097

0.542

2777

0.093 (0.059, 0.145)

Ciprofloxacin

0.979

0.159

2405

0.482 (0.437, 0.528)

Levofloxacin

< 0.001

0.015

247,151

0.207 (0.181, 0.235)

Moxifloxacin

0.422

0.276

5131

0.164 (0.115, 0.228)

Norfloxacin

< 0.001

0.358

1

0.450 (0.257, 0.659)

Sparfloxacin

0.128

> 0.999

252

0.165 (0.056, 0.395)

Ofloxacin

0.290

0.858

515

0.280 (0.185, 0.400)

Trovafloxacin

0.160

0.358

1041

0.099 (0.063, 0.153)

Tetracyclines

Tetracycline

< 0.001

0.497

249

0.643 (0.494, 0.769)

Doxycycline

0.019

0.165

763

0.097 (0.043, 0.207)

Tigecycline

0.568

0.710

10,995

0.214 (0.154, 0.291)

Minocycline

< 0.001

0.003

32,012

0.064 (0.042, 0.096)

Sulfonamides

Trimethoprim/ sulfamethoxazole

< 0.001

0.436

399,468

0.196 (0.171, 0.224)

Trimethoprim

0.343

0.440

5604

0.141 (0.091, 0.214)

Polymyxins

Colistin

0.561

0.951

206

0.446 (0.371, 0.525)

Other

Chloramphenicol

0.023

0.888

8714

0.338 (0.276, 0.406)

Rifamycin

Rifampin

0.229

0.333

71

0.877 (0.613, 0.970)